top of page

Figen Yargucu Zihni

Öğrenim Durumu:

Tıp Fakültesi - Ege Üniversitesi - Tıp öğrencisi - 1995-2001

İç hastalıkları Ana Bilim Dalı - Ege Üniversitesi Tıp Fakültesi - Araştırma görevlisi - 2002-2007

İç Hastalıkları Ana Bilim Dalı Romatoloji Bilim Dalı - Ege Üniversitesi Tıp Fakültesi - Yan dal uzmanlık öğrencisi - 2007-2011

Görevler:

2011

Romatoloji uzmanı

Mersin Devlet Hastanesi Romatoloji Polikliniği

2011 - 2013

Romatoloji uzmanı

İzmir Bozyaka Eğitim Araştırma Hastanesi, İç Hastalıkları Kliniği

2013 -

Doktor Öğretim Üyesi

Ege Üniversitesi Tıp Fakültesi, İç Hastalıkları Ana Bilim Dalı, Romatoloji Bilim Dalı

KLİNİK ARAŞTIRMALARLA İLGİLİ GENEL BİLGİLER

1. İyi Klinik Uygulamaları (İKU) ve klinik araştırma konularında alınan eğitim/sertifika bilgileri:

Ege Üniversitesi ve Klinik Araştırmalar Derneği İş birliği ile Temel İyi Klinik Uygulamalar Eğitimi, 23.01.2014

2. Görev alınan klinik araştırma bilgileri:

MA21056 Score Study 2009-2010 Faz III Çalışma: A randomized, placebo controlled multicenter clinical study investigating efficacy of rituximab (MabThera/Rituxan) in the inhibition of joint structural damage assesed by magnetic resonance imaging in patients with rheumatiod arthtritis and inadequate response to methotrexate; Roche - 2008-2010 - Yardımcı Araştırıcı

WA20500/ACT4072g Ocrelizumab Belong Study 2009 Faz III Çalışma: A randomised, double-blind, placebo-controlled paralel-group, multicenter study to evaluate the efficacy and safety of two doses of ocrelizumab in patients with WHO or ISN Class III or IV nephritis due to systemic lupus erythematosus. Hoffmann-La Roche - 2009-2010 - Yardımcı Araştırıcı

CACZ885H2251 protokol numaralı “A 24-week, dose-ranging, multi-center, double-blind, double-dummy, active-controlled study to evaluate canakinumab (ACZ885) for prophylaxis of signs and symptoms of acute flares in chronic gout patients initiating allopurinol therapy “çalışması - 2009-2010 - Yardımcı araştırıcı

ACZ885H2251 protokol numaralı “A 24-week, open-label, multicentre, follow-up and extension study to CACZ885H2251, to assess safety, tolerability and efficacy of canakinumab (ACZ885) in patients with gout who are given canakinumab at the time of acute flare” çalışması - 2009-2010 - Yardımcı araştırıcı

ML25095 ACTRA Study 2013- Faz III Çalışma: A study of RoActemra/Actemra (Tocilizumab) in patients with moderate to severe rheumatoid arthritis. Roche - 2012-2013 - Sorumlu Araştırmacı

Allergan 192024-091/092 protokol numaralı “Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-angle Glaucoma or Ocular Hypertension Faz III Çalışma - 2016-….. - Yardımcı Araştırmacı

 

MA21056 Score Study 2009-2010 Faz III Çalışma: A randomized, placebo controlled multicenter clinical study investigating efficacy of rituximab (MabThera/Rituxan) in the inhibition of joint structural damage assesed by magnetic resonance imaging in patients with rheumatiod arthtritis and inadequate response to methotrexate; Roche - 2008-2010 - Yardımcı Araştırıcı

 

WA20500/ACT4072g Ocrelizumab Belong Study 2009 Faz III Çalışma: A randomised, double-blind, placebo-controlled paralel-group, multicenter study to evaluate the efficacy and safety of two doses of ocrelizumab in patients with WHO or ISN Class III or IV nephritis due to systemic lupus erythematosus. Hoffmann-La Roche - 2009-2010 - Yardımcı Araştırıcı

CACZ885H2251 protokol numaralı “A 24-week, dose-ranging, multi-center, double-blind, double-dummy, active-controlled study to evaluate canakinumab (ACZ885) for prophylaxis of signs and symptoms of acute flares in chronic gout patients initiating allopurinol therapy “çalışması - 2009-2010 - Yardımcı araştırıcı

ACZ885H2251 protokol numaralı “A 24-week, open-label, multicentre, follow-up and extension study to CACZ885H2251, to assess safety, tolerability and efficacy of canakinumab (ACZ885) in patients with gout who are given canakinumab at the time of acute flare” çalışması - 2009-2010 - Yardımcı araştırıcı

ML25095 ACTRA Study 2013- Faz III Çalışma: A study of RoActemra/Actemra (Tocilizumab) in patients with moderate to severe rheumatoid arthritis. Roche - 2012-2013 - Sorumlu Araştırmacı

Allergan 192024-091/092 protokol numaralı “Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-angle Glaucoma or Ocular Hypertension Faz III Çalışma - 2016-….. - Yardımcı Araştırmacı

YAYINLAR

  1. Sahin F, Turk UO, Yargucu F, Donmez A, Cagirgan S. Hypothermia during the infusion of cryopreserved autologous peripheral stem cell causes electrocardiographical changes: report of two cases. Am J Hematol. 2006 Aug;81(8):627-30

  2. Oksel F, Tarhan F, Bayraktaroğlu S, Savaş R, Yargucu F, Keser G. Radiological incomplete thymus involution in systemic sclerosis. Rheumatology (Oxford). 2009 Jul;48(7): 800–3. doi: 10.1093/rheumatology/kep055. Epub 2009 May 15.

  3. Kabasakal Y, Kitapcioglu G, Yargucu F, Taylan A, Argin M, Gumusdis G. Efficacy of SLZ and MTX (alone or combination) on the treatment of active sacroiliitis in early AS. Rheumatol Int. 2009 Oct;29(12):1523–7. doi: 10.1007/s00296-009-1057-6. Epub 2009 Jul 11.

  4. Karadag O, Aksu K, Sahin A, Zihni FY, Sener B, Inanc N, Kalyoncu U, Aydin SZ, Ascioglu S, Ocakci PT, Bilgen SA, Keser G, Inal V, Direskeneli H, Calguneri M, Ertenli I, Kiraz S. Assessment of latent tuberculosis infection in Takayasu arteritis with tuberculin skin test and Quantiferon-TB Gold test. Rheumatol Int. 2010 Sep;30(11):1483–7. doi: 10.1007/s00296-010-1444-z. Epub 2010 Apr 1.

  5. Emre S, Kayikçioğlu O, Ateş H, Cinar E, Inceoğlu N, Yargucu F, Pirildar T, Oksel F. Corneal hysteresis, corneal resistance factor, and intraocular pressure measurement in patients with scleroderma using the reichert ocular response analyzer.Cornea. 2010 Jun;29(6):628–31. doi: 10.1097/ICO.0b013e3181c3306a.

  6. Emmungil H, Kalfa M, Zihni FY, Karabulut G, Keser G, Sen S, Aksu K. Interstitial cystitis: a rare manifestation of primary Sjogren’s syndrome successfully treated with low dose cyclosporine. Rheumatol Int. 2011 Jan 22. doi: 10.1007/s00296-010-1782-x. Epub 2011 Jan 22.

  7. Karabulut G, Kitapcioglu G, Inal V, Kalfa M, Yargucu F, Keser G, Emmungil H, Gokmen NM, Kocanaogullari H, Aksu K. Cigarette smoking in primary Sjögren's syndrome: positive association only with ANA positivity. Mod Rheumatol. 2011 Mar 30. doi: 10.1007/s10165-011-0446-3. Epub 2011 Mar 30.

  8. Zihni FY, Kalfa M, Ocakçı PT, Tarhan F, Parildar M, Keser G, Aksu K. Coexistence of Takayasu's arteritis with familial Mediterranean fever. Rheumatol Int. 2011 Mar 18. doi: 10,1007/s00296-011-1853-7. Epub 2011 Mar 18.

  9. Meier FM, Frommer KW, Dinser R, Walker UA, Czirjak L, Denton CP, Allanore Y, Distler O, Riemekasten G, Valentini G, Müller-Ladner U; EUSTAR Co-authors. Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database. Ann Rheum Dis. 2012 Aug;71(8):1355–60. doi:10.1136/annrheumdis–2011–200742

  10. Emmungil H, Durusoy R, Kalfa M, Yargucu Zihni F, Özmen M, Keser G, Gücenmez S, Yilmaz Z, Aksu K. Plasma thiopurine S-methyltransferase levels and azathioprine-related adverse events in patients with Behçet's disease. Clin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S40-5. Epub 2015 May 1.

  11. Comments on the development of aortic structural damage (aneurysm or dilatation) in patients with giant cell arteritis. Keser G, Tekeoglu S, Yargucu Zihni F, Aksu K. Clin Exp Rheumatol. 2016 Jan-Feb;34(1 Suppl 95): S14. Epub 2015 Jun 19

  12. Kalfa M, Kocanaogullari H, Yargucu Zihni F, Karabulut G, Emmungil H, Inal V.Therapy resistant idiopathic scleredema: an underlying pathology not always present. European Journal of Rheumatology. Volume: 2 Issue: 4 Pages: 163-164 Published: DEC 2015

  13. Tanıgör G, Karabulut G, Çelebisoy N, Eraslan C, Zihni FY. Stroke presenting with an isolated foot drop in a patient with antiphospholipid syndrome: an uncommon clinical entity. Neurol Sci. 2019 Jan;40(1):193-194. doi: 10.1007/s10072-018-3552-6. Epub 2018 Aug 31.

  14. Sürgeç E, Can H, Döşkaya M, Karakavuk M, Atalay Şahar E, Değirmenci Döşkaya A, Pullukçu H, Taşbakan M, Sezai Taşbakan M, Akyol D, Yargucu Zihni F, Ün C, Yüksel Gürüz A, Demir S. Genotyping of Pneumocystis jirovecii isolates obtained from clinical samples by multilocus sequencing: a molecular epidemiology study conducted in Turkey. Arch Microbiol. 2020 Sep;202(7):1647-1652. doi: 10.1007/s00203-020-01874-3. Epub 2020 Apr 9.

  15. Meier FM, Frommer KW, Dinser R, Walker UA, Czirjak L, Denton CP, Allanore Y, Distler O, Riemekasten G, Valentini G, Müller-Ladner U; EUSTAR Co-authors. Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database. Ann Rheum Dis. 2012 Aug;71(8):1355-60. doi:10.1136/annrheumdis-2011-200742. Epub 2012 May 21.

  16. Wu W, Jordan S, Graf N, de Oliveira Pena J, Curram J, Allanore Y, Matucci-Cerinic M, Pope JE, Denton CP, Khanna D, Distler O; EUSTAR Collaborators. Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort. Ann Rheum Dis. 2019 May;78(5):648-656. doi: 10.1136/annrheumdis-2018-213455. Epub 2019 Mar 9.

  17. Elhai M, Boubaya M, Distler O, Smith V, Matucci-Cerinic M, Alegre Sancho JJ, Truchetet ME, Braun-Moscovici Y, Iannone F, Novikov PI, Lescoat A, Siegert E, Castellví I, Airó P, Vettori S, De Langhe E, Hachulla E, Erler A, Ananieva L, Krusche M, López-Longo FJ, Distler JHW, Hunzelmann N, Hoffmann-Vold AM, Riccieri V, Hsu VM, Pozzi MR, Ancuta C, Rosato E, Mihai C, Kuwana M, Saketkoo LA, Chizzolini C, Hesselstrand R, Ullman S, Yavuz S, Rednic S, Caimmi C, Bloch-Queyrat C, Allanore Y; for EUSTAR network. Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study. Ann Rheum Dis. 2019 Jul;78(7):979-987. doi: 10.1136/annrheumdis-2018-214816. Epub 2019 Apr 9.

  18. Sobanski V, Giovannelli J, Allanore Y, Riemekasten G, Airò P, Vettori S, Cozzi F, Distler O, Matucci-Cerinic M, Denton C, Launay D, Hachulla E; EUSTAR Collaborators. Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis.

  19. Arthritis Rheumatol. 2019 Sep;71(9):1553-1570. doi: 10.1002/art.40906. Epub 2019 Aug 12.

  20. Becker M, Graf N, Sauter R, Allanore Y, Curram J, Denton CP, Khanna D, Matucci-Cerinic M, de Oliveira Pena J, Pope JE, Distler O; EUSTAR Collaborators, EUSTAR Collaborators (numerical order of centres). Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis. Ann Rheum Dis. 2019 Sep;78(9):1242-1248. doi: 10.1136/annrheumdis-2019-215145. Epub 2019 Jun 21.

  21. Hughes M, Heal C, Siegert E, Hachulla E, Airó P, Riccardi A, Distler O, Matucci-Cerinic M; EUSTAR Collaborators. Significant weight loss in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis. 2020 Aug;79(8):1123-1125. doi: 10.1136/annrheumdis-2020-217035. Epub 2020 Mar 25.

  22. Hoffmann-Vold AM, Allanore Y, Alves M, Brunborg C, Airó P, Ananieva LP, Czirják L, Guiducci S, Hachulla E, Li M, Mihai C, Riemekasten G, Sfikakis PP, Kowal-Bielecka O, Riccardi A, Distler O; EUSTAR collaborators. Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database. Ann Rheum Dis. 2021 Feb;80(2):219-227. doi: 10.1136/annrheumdis-2020-217455. Epub 2020 Sep 28.

  23. PMID: 32988845 Free PMC article.

  24. Adiguzel S, Palamar M, Yargucu F, Oksel F, Yagci A.Evaluation of Ocular Surface and Meibomian Glands in Patients With Scleroderma. Cornea. 2021 Aug 1;40(8):977-981. doi: 10.1097/ICO.0000000000002551.

  25. Allanore Y, Bozzi S, Terlinden A, Huscher D, Amand C, Soubrane C, Siegert E, Czirják L, Carreira PE, Hachulla E, Zanatta E, Li M, Airò P, Mendoza FA, Rosato E, Distler O; EUSTAR Collaborators. Health Assessment Questionnaire-Disability Index (HAQ-DI) use in modelling disease progression in diffuse cutaneous systemic sclerosis: an analysis from the EUSTAR database. Arthritis Res Ther. 2020 Oct 28;22(1):257. doi: 10.1186/s13075-020-02329-2.

  26. Çelebisoy N, Güleç F, Bayrakçı A, Yargucu F. Longitudinal Myelitis As The First Manifestation of Systemic Lupus Erythematosus. Journal of Neurological Sciences [Turkish] 26:(4);21;492–494, 2009

  27. Sezgin AO, Türk BG, Ertam I, Zihni FY, Kazandı AC, Ünal I. A Case of Psoriasis Complicated with Systemic Lupus Erythematosus.Turk Acad Dermatol 2010; 4 (4): 04403c

  28. Bozkurt D, Yargucu F, Ceylan N, Sarsık B. Sinüzit, Miyokardit, Akciğerde Kitle ve Hızla İlerleyen Glomerülonefrit: Wegener Granülomatozu. Turk Neph Dial Transpl 2010;19;1,69–72.

  29. Yargucu Zihni F, Keser G. İmmünglobülin G4 ilişkili hastalık. RAED Dergisi 2014; Çevrimiçi (Online) Erken Bask›. © 2014 RAED doi:10.2399/raed.14.10820

  30. Yargucu Zihni F, Keser G. Non-radyografik aksiyal spondiloartrit kavramı. Turkiye Klinikleri J Immunol Rheumatol-Special Topics, 2015

  31. Yargucu Zihni F. Sistemik sklerozda böbrek tutulumu. Türkiye Klinikleri Dergisi Sistemik Skleroz Özel Sayısı. 2015 Cilt:8 Sayı:2 Sayfa:47-5.

  32. Keser G, Yargucu Zihni F. Sistemik lupus eritematozus epidemiyolojisi. Türkiye Klinikleri Dergisi Sistemik Lupus Eritematozus Özel Sayısı. 27.12.2015

  33. Ardeniz FÖ. Yargucu Zihni F, Erdoğan AP, Yıldırım Şimşir I. RANKL/RANK/OPG' nin immün sistemdeki rolleri. Turkiye Klinikleri J Immun Allergy Special Topics, cilt.9, ss.1-9, 2016

  34. Yargucu Zihni F. Osteoimmunolojiye romatolojik yaklaşım. Türkiye Klinikleri Dergisi Osteoimmunoloji Özel Sayısı 08.03.2016

  35. Yargucu Zihni F. Psöryatik artrit; genetik özellikleri. Türkiye Klinikleri Dergisi Türkiye Klinikleri Dergisi Psöryatik Artrit Özel Sayısı 30.01.2016

  36. BOZKURT D., YARGUCU ZİHNİ F., CEYLAN N., SARSIK KUMBARACI B. Insidious Disaster Composed of Sinusitis, Myocarditis, Lung Mass And Rapidly Progressive Glomerulonephritis: Wegener Granulomatosis. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, cilt.19, sa.1, ss.69-72, 2010

  37. Ok ES, Tatar E, Yeniay KP, Yargucu Zihni F et al. An Uncommon Presentation of HDR Syndrome: Distal Renal Tubular Acidosis in a Patient with Sjogren's Syndrome . TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNALVolume: 24Issue: 3Pages: 318-320Published: 2015

Bilimsel Kuruluşlara Üyelikler:

  1. Türkiye Romatoloji Derneği

  2. EUSTAR (EULAR (European League Against Rheumatism) Scleroderma Trials And Research

  3. EMEUNET (EULAR (European League Against Rheumatism) Working Group of Young clinicians and Researchers in Rheumatology- The Emerging EULAR Network)

Bizi sosyal medya hesaplarımızdan takip edebilirsiniz.

  • Figen Yargucu Zihni Instagram
  • Gonca Karabulut Instagram
bottom of page